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pentobarbital will decrease the extent or effect of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unfamiliar.pentobarbital will reduce the extent or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.Contraindicated (1)pentobarbital will lower the extent or eff